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Mehta, R. S.
- Analgesic and Anti-inflammatory Activity of Couroupita guianensis Aubl.
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Journal of Natural Remedies, Vol 4, No 1 (2004), Pagination: 52-55Abstract
Objective: To study analgesic and anti-inflammatory activity of various extracts of flowers and bark of Couroupita guianensis Aubl. Materials and methods: Analgesic activity was evaluated using tail flick method and anti-inflammatory activity was screened by measuring the reduction in carrageenan induced hind paw oedema. The potency of various extracts of flower and bark were compared with (i) paracetamol (200 mg/kg) for analgesic and (ii) indomethacin (10 mg/kg) for anti-inflammatory activities. Results: All the extracts of C. guianensis showed analgesic and anti-inflammatory activity. The peak analgesic effect of flower was seen after 1 h while bark extracts showed peak effect after 2 h. Maximum reduction in inflammation by the extracts was observed after 3 h. Conclusion: C. guianensis is almost equipotent to paracetamol in its analgesic activity and to indomethacin in its anti-inflammatory activity. So it can be recommended for further studies.Keywords
Couroupita guianensis, Analgesic Activity, Anti-inflammatory Activity, Paracetamol, Indomethacin- Hepatoprotective Activity of a Benzopyrone from Tephrosia purpurea Pers
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Journal of Natural Remedies, Vol 5, No 2 (2005), Pagination: 115-120Abstract
Objective: To study hepatoprotective activity of a new benzopyrone derivative (TP) isolated from the alcoholic extract of aerial parts of Tephrosia purpurea Pers. Materials and methods: Compound TP was isolated from alcoholic extract of T. purpurea by normal phase column chromatography using toluene: ethyl acetate (70:30) as mobile phase and structure was elucidated by spectroscopic methods. Hepatoprotective activity of TP and the alcoholic extract was evaluated using carbon tetrachloride, paracetamol and rifampicin as toxicants. The potency of TP (100 mg/kg) and the alcoholic extract of aerial parts (200 mg/kg), was compared with silymarin (100 mg/kg). The SGOT, SGPT, total and direct bilirubin levels of blood were measured spectrophotometrically. Results: Compound TP was found to be 3-hydroxy, 6-methoxy, 2-oxy (3-butanone), 7 (dioxolane-4-one), 2, 3,-dihydrobenzopyrone. The alcoholic extract and TP caused significant fall in the enzyme levels in serum in rats. Conclusion: Alcoholic extract of T. purpurea and TP have shown significant hepatoprotective activity in rats against all the toxicants that were studied.Keywords
Tephrosia Purpurea, Hepatoprotective Effect, Carbon Tetrachloride, Paracetamol Rifampicin, Silymarin- Antifertility Activity of Artabotrys odoratissimus Roxb. and Couroupita guianensis Aubl
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Journal of Natural Remedies, Vol 5, No 2 (2005), Pagination: 121-125Abstract
Objective: To study antifertility activity of various extracts of A. odoratissimus Roxb. and C. guianensis Aubl. Materials and methods: Antifertility activity of benzene, ethanol and water extracts of leaves of A. odoratissimus and bark and flowers of C. guianensis was studied for their effect on duration of various stages of oestrus cycle in adult female rats and on the number implantation sites in the pregnant rats. Results: All the extracts of A. odoratissimus leaf and ethanol and water extracts of C. guianensis bark and flower showed significant prolongation of dioestrus stage (p<0.05). Ethanol and water extracts of A. odoratissimus leaf showed anti-implantation effect. Ethanol extract of C. guianensis bark and all the extracts of its flower reduced the number of implantations. Conclusion: The disturbances in the reproductive cycle indicate effect of these plants on the sex hormones in the animals. Prevention of implantation may be due their interference in the receptive stage of the uteri and endometrial sensitivity for decidualisation. The results suggest that the both plants are having antifertility activity and possible therapeutic use.- Antidiabetic Activity of Novel Androstane Derivatives from Syzygium cuminii Linn.
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Journal of Natural Remedies, Vol 7, No 2 (2007), Pagination: 214-219Abstract
Objective: To study antidiabetic activity of two novel androstane derivatives (JB1 and JB2) isolated from the ethanolic extract of seeds of Syzygium cuminii Linn. Materials and methods: Compounds JB1 and JB2 were isolated from ethanolic extract of seeds of S. cuminii by normal phase column chromatography using toluene: ethyl acetate (80:20) as mobile phase and their structure was elucidated by spectroscopic methods. Antidiabetic activity of JB1 and JB2 and the ethanolic extract was evaluated using alloxan as diabetogenic agent. The potency of JB1 and JB2 (100 mg/kg) and the ethanolic extract (200 mg/kg), was compared with glibenclamide (5 mg/kg). The elevated blood glucose levels were monitored colorimetrically using glucose oxidase enzyme system. Results: Compound JB1 was found to be 3, 15-dihydroxy Δ3 androstene [16, 17-C] (6' methyl, 2'- 1, 3-dihydroxy-1-propene) 4H pyran whereas JB2 to be 3-hydroxy androstane [16, 17-C] (6' methyl, 2'-1-hydroxy-isopropene-1-yl) 4, 5, 6 H pyran. Ethanolic extract of seeds of S. cuminii reduced elevated blood glucose levels in alloxan-induced diabetes in rats on single dose as well as prolonged treatment. Compound JB1 was found to be more effective than JB2 as it showed peak activity at the end of day three, which was comparable to ethanolic extract.Keywords
Syzygium cuminii Linn., Anti-diabetic Activity, Glibenclamide, Alloxan- Preliminary Evaluation of Hepatoprotective Activity of Trianthema portulacastrum Linn.
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Journal of Natural Remedies, Vol 3, No 2 (2003), Pagination: 180-184Abstract
Objective: To study hepatoprotective effect of aerial parts of Trianthema portulacastrum. Materials and methods: Hepatoprotective activity of T. portulacastrum was evaluated using paracetamol and rifampicin as liver toxicants in rats. The potency of alcoholic and aqueous extracts of aerial parts was compared with that of silymarin at a dose of 100 mg/kg, P.O. The SGOT, SGPT and bilirubin levels of blood were measured spectrophotometrically. Results: Alcoholic extract of aerial parts caused significant fall in the enzyme levels in serum in rats. Conclusion: T. portulacastrum has shown significant activity in rats toxicated with paracetamol and rifampicin and can be recommended for further studies.Keywords
Trianthema portulacastrum, Hepatoprotective Activity, Paracetamol, Rifampicin, Silymarin- Simultaneous Estimation of Lansoprazole and Domperidone in Combined Dosage Form by RP-HPLC
Authors
1 Ramanbhai Patel College of Pharmacy, Changa, Gujarat, IN
2 Department of Pharmaceutical Analysis, Veerayatan Institute of Pharmacy, Kutch, Gujarat, IN
3 Veeda, Ahmedabad, Gujarat, IN
4 A.R. College of Pharmacy, Vallabh Vidhyanagar, Gujarat, IN
Source
Asian Journal of Research in Chemistry, Vol 2, No 2 (2009), Pagination: 210-212Abstract
A RP-HPLC method has developed for simultaneous estimation of lansoprazole and domperidone in combined capsule dosage form. Lansoprazole is a proton pump inhibitor and used in the treatment of duodenal and gastric ulcers and gastroesophageal reflux disease (GERD), a condition in which the acid in the stomach washes back up into the esophagus. Sometimes lansoprazole is used in combination with antibiotics to treat ulcers associated with infection caused by the H. pylori bacteria, gastro-oesophageal reflux disease (GERD), peptic ulcer and Zollinger-Ellison syndrome. Domperidone is indicated for treating symptoms associated with upper gastrointestinal motility disorders caused by chronic and sub acute gastritis. It is a gastrointestinal emptying (delayed) adjunct, a peristaltic stimulant and exhibit antiemetic properties.
The mobile phase used was a combination of Acetonitrile: Methanol (81:19). The detection of the combined dosage form was carried out at 280 nm and a flow rate employed was 1 ml/min. The retention time for lansoprazole and domperidone has found to be 2.8 and 1.57 min respectively. Linearity was obtained in the concentration range of 8-24 μg/ml of lansoprazole and 8-24 μg/ml of domperidone with a correlation coefficient of 0.9977 and 0.9992. Detector consists of photodiode array detector; the reversed phase column used was RP-C18 (2.27μm size, 250 mm´4.6 mm i.d.) at ambient temperature. The developed method was validated according to ICH guidelines and values of accuracy, precision and other statistical analysis were found to be in good accordance with the prescribed values. Thus the proposed method was successfully applied for simultaneous determination of domperidone and lansoprazole in routine analysis.
Keywords
Simultaneous Estimation, RP-HPLC, Lansoprazole(LAN), Domperidone(DOM).- Quality Assessment of Kushta-e-Gaodanti:A Traditional Unani Medicine
Authors
1 College of Pharmacy, IPS Academy, Indore [M.P], IN
2 School of Pharmacy, Devi Ahilya University, Indore [M.P], IN
3 A R College of Pharmacy, Vallabh Vidyanagar [Gujarat], IN
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Asian Journal of Research in Chemistry, Vol 1, No 1 (2008), Pagination: 46-50Abstract
Kushta-e-gaodanti was prepared as per the method mentioned in Unani formulary. The raw materials, intermediates obtained during the preparation of kushta and the final product were characterized using modern analytical techniques like Fourier transform infra-red spectroscopy (FTIR). X-ray powder diffraction (XRPD) and thermo gravimetric analysis (TGA). The study shows that the mineral Gaodanti (calcium sulphate dihydrate) is converted into calcium sulphate hemi hydrate on first calcination in earthen pot sealed with the process gil-e-hikmat. Further on calcination this intermediate is transformed to kushta-e-gaodanti which is orthorhombic α-calcium sulphate anhydride. Kushta-e-gaodanti is a fine powder with particle size 7-8 micrometer, calcium content 29.32%, bulk density 0.928, tapped density 1.268, angle of repose 36.67° and the value of Carr’s index is 47.08. Loss on drying at 110°C and loss on ignition was not more than 0.5 %w/w and 0.05% w/w respectively. Microbial load of the preparation was found negative for the presence of Escherichia coli, Salmonella species and Staphylococcus aureus. Total aerobic count was under acceptance limit. Trace element analysis of bhasma by ICP-OES revealed the presence of some other important metals like arsenic, lead, chromium, cadmium, mercury, tin under acceptable limits at prescribed dose.Keywords
FTIR, Calcination, Unani Traditional Medicine.- Grewia tenax (Frosk.) Fiori – popularization, conservation and utilization of lesser known multipurpose shrub
Authors
1 ICAR-Central Arid zone Research Institute, Regional Research Station, Pali-Marwar 306 401, IN
2 ICAR-Indian Agricultural Research Institute, Hazaribagh 825 405, IN
Source
Current Science, Vol 120, No 10 (2021), Pagination: 1557-1558Abstract
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No KeywordsReferences
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